Correo Electrónico
DNINFOA – SIA
Bibliotecas
Convocatorias
Estudio y Aprovechamiento de Productos Naturales Marinos y Frutas de Colombia
About Us:
Colombia ranks among the ten most biologically diverse countries in the world. This rich biodiversity is reflected in a vast chemical diversity that remains largely unexplored. Natural products derived from this diversity hold immense value, not only from an economic perspective but also due to their potential to address contemporary societal challenges, such as human, animal, and plant diseases; to serve as sources of new materials; and to provide applications in fields like cosmetics. Within this context, the primary objectives of our research group are as follows: 1. To generate chemical and technological knowledge on the compounds derived from Colombia’s biodiversity, including terrestrial plants, microorganisms, marine organisms, and invertebrates.
1) To generate chemical and technological knowledge on the compounds derived from Colombia’s biodiversity, including terrestrial plants, microorganisms, marine organisms, and invertebrates. 2) To assess the economic potential of the species under investigation, exploring whether their natural products can be utilized by industries such as phytomedicines, biocontrol agents, nutraceuticals, pharmaceuticals, and as additives in products like paints. 3) To contribute to the training of high-level researchers in the country and foster the development of research institutions.
Our expertise includes the isolation and identification of organic molecules (e.g., terpenes, peptides, polyketides) from natural sources, including microorganisms. This experience spans from highly polar to volatile molecules. We employ advanced tools for compound identification through dereplication, as well as de novo methods (1D and 2D NMR), including the determination of relative and absolute stereochemistry. Recently, we have incorporated techniques such as metabolomics (using NMR and mass spectrometry) and mass spectrometry-based molecular networking to prioritize organisms for identification. We also correlate these data with biological activity, enabling us to identify the compounds responsible for the observed activity
Research topics
Marine Natural Products: Our research focuses on the chemistry of octocorals, sponges, and algae, with an emphasis on discovering compounds with biological activity. Currently, we employ metabolomic tools to aid in this exploration.
Phytochemistry: We aim to develop phytomedicines, collaborating with pharmaceutical researchers to study species such as Passiflora, Hypericum, and Physalis.
Biotechnology: We are investigating the chemical diversity offered by marine microorganisms, particularly as a source of compounds capable of controlling phytopathogens. Our work has encompassed the study of cyanobacteria, Firmicutes, actinobacteria, and fungi.
Synthesis and Semisynthesis: We are focused on obtaining semisynthetic derivatives that demonstrate enhanced biological activity compared to compounds isolated from natural sources. We also seek to identify the structural modifications responsible for these improvements in activity
Lead Researchers
LEONARDO CASTELLANOS HERNÁNDEZ. Chemist M.Sc. Ph.D.
Full Professor, Investigador Senior
lcastellanosh@unal.edu.co
Professor Castellanos is a chemist with a Master’s and Ph.D. in Natural Products from the
National University of Colombia. He completed a postdoctoral fellowship in metabolomics at Leiden University, The Netherlands. His expertise in organic chemistry spans marine natural products, chemical studies of microorganisms, biotechnology, metabolomics, and semi-synthesis. He has authored over 80
research articles, with a focus on marine organisms (macro and micro) and Passiflora chemistry. Professor Castellanos is a Senior Researcher recognized by Minciencias and a tenured professor of Organic Chemistry at the National University of Colombia.
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ORCID ID 0000-0001-5248-800X
GoogleScholar
ResearchGate
FREDDY ALEJANDRO RAMOS RODRIGUEZ. Chemist M.Sc. Ph.D.
Full Professor, Investigador Senior
faramosr@unal.edu.co
Prof. Ramos is a Chemist, MSc. in Chemistry and PhD. in Pharmaceutical Sciences in the field of Natural Product Chemistry. Professor at the Universidad Nacional de Colombia. Expert in isolation and structure elucidation of bioactive compounds from marine natural sources, including marine invertebrates, microorganisms and plants. Expert in modern spectroscopic NMR and LCMS techniques including metabolomics approaches. He has over 60 articles published in natural products. In the last years he has been working in development of biocontrol agents from marine microorganisms.
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GoogleScholar
ResearchGate
ORCID 0000-0002-9271-7193
CARMENZA DUQUE BELTAN. Chemist M.Sc. Ph.D.
Full Professor
Founder of the Research Group
Dr. Carmenza Duque Beltán is a chemist and the founder of the research group. She is recognized as a leading figure in Latin America in the fields of marine natural products and flavor chemistry research
PosDoc researchers
VANESSA URREA-VICTORIA
Biologist, Ph.D.
vurreav@unal.edu.co
Vanessa Urrea-Victoria is a biologist (Pontificia Universidad Javeriana, Colombia) with a Ph.D. in Science from the Universidade de São Paulo (Brazil), specializing in the physiology and chemistry of marine macroalgae. Her expertise spans the cultivation of microalgae and macroalgae, fish reproduction (e.g., seahorses), and the analysis of abiotic stress factors such as temperature and UV radiation. She has conducted postdoctoral research at the National University of Colombia, focusing on the characterization of photoprotective compounds, specifically mycosporine-like amino acids (MAAs), in marine macroalgae from the Colombian Pacific and Caribbean, utilizing chromatographic techniques such as HPLC-DAD and HPLC-DAD-MS/MS.
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ORCID 0000-0002-5049-7102
Research Gate
PhD students
Master Students
ANA RUTH CAICEDO
ancaicedoo@unal.edu.co
A bacteriologist by profession from the University Colegio Mayor de Cundinamarca, currently pursuing a Master’s degree in Biochemistry at the National University of Colombia. With experience in microbiology and molecular biology techniques, as well as in studying the biological activities of microorganisms and extraction processes, this individual is particularly interested in research and development of natural products derived from microorganisms for use in biocontrol activities, with applications in controlling plant and animal pathogens.
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MARIA CAMILA CABEZA PULIDO
mcabezap@unal.edu.co
Pharmaceutical chemist by profession. Currently pursuing a Master’s degree in Pharmaceutical Sciences at a National University of Colombia, with expertise in natural products, biological activities of cosmetic interest, as well as in the research and development of cosmetic products. Interested in the innovation of cosmetic products using natural ingredients and their technological transfer to local enterprises. Passionate about sports, music, and scientific outreach.
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ResearchGate
DANIELA FERNANDA OCHOA SANCHEZ
dfochoas@unal.edu.co
Pharmaceutical Chemist, with a background in natural products, experienced in extracting active compounds from microbial sources, determining antifungal activity using various methods such as agar well diffusion, direct confrontations, and microdilution in a plate. Also skilled in evaluating the safety of extracts and microorganisms, with an interest in formulating different delivery systems. Trained in metabolomic tools and molecular networks for the study and analysis of microbial extracts.
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EIBAR ANGULO SANCHEZ
eangulon@unal.edu.co
A young Colombian chemist currently pursuing a Master’s degree in Chemical Sciences at the National University of Colombia, with a focus on researching marine natural products for cosmetics and sustainable resource utilization. Passionate about exploring the chemistry of marine ecosystems and their potential applications in the cosmetics industry. In addition to their academic pursuits, they are also interested in languages, literature, and sports, which enhance their approach to problem-solving in chemical sciences.
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JESSICA GONZALEZ TORRES
jegonzalezto@unal.edu.co
A chemist and Master’s student in chemical sciences at the Universidad Nacional de Colombia, specializing in marine natural products derived from the macroalgae Hypnea spp. They have actively contributed to the laboratory cultivation of this macroalgae and are focused on the sustainable production of its natural products for cosmetic applications. Enthusiastic about language learning, they have basic proficiency in Italian, English, and German, and are currently studying French. Outside the lab, they enjoy dancing.
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WILSON DAVID BLANCO MARIÑO
wblancom@unal.edu.co
Chemistry professional, Master’s student in Science – Chemistry from the National University of Colombia with an emphasis on research in natural products. Trained in tools used in the study and research of natural products, such as extraction, isolation and separation processes, chromatography, spectrometry, spectroscopy, metabolomics, among others. Currently interested in the research of metabolites from microorganisms for use in the control of phytopathogens.
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Undergraduate Students
Alejandra Patiño
alpatinos@unal.edu.co
Chemistry student in 8th semester at the Universidad Nacional de Colombia, with great interest in the fields of organic chemistry, biochemistry and microbiology. Currently working in the quantification of compounds with commercial potential obtained from algae. Passionate about language learning, reading and music.
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Kerly Dayana Cortés Hernández
kcortesh@unal.edu.co
Chemistry student in 7th semester at the Universidad Nacional de Colombia, interested and passionate about biotechnology, chemistry of natural products and food, as well as organic and environmental chemistry. Passionate about sports such as volleyball and formula one, and other activities such as culture, music, read, write and scientific outreach.
Edison Javier Jaimes Cáceres
ejaimes@unal.edu.co
Chemistry student in 9th semester, interested in organic synthesis, microbiology, spectroscopy and chromatography techniques. Willing to learn new things day by day and to give the best of himself for the community and the academy. He likes sports like soccer and basketball, and has other hobbies like drawing, dancing and reading.
Barbara Daniela Ramírez Bermúdez
bramirezb@unal.edu.co
Chemistry student in 7th semester, with interest in natural products chemistry, alongside organic synthesis, medicinal chemistry, spectroscopy and biochemistry. Eager to learn about a different variety of topics related to academia, like scientific communication and divulgation, which she currently works on in the ACS Student Chapter at National University of Colombia. She is also passionate about language learning, and she likes to read, write, as well as learning violin and music in her spare time.
Dilan Stif Sierra Quintero
aigilac@unal.edu.co
Chemistry student in the ninth semester, interested in natural products chemistry, microbiology, environmental chemistry, spectroscopy, biochemistry and genetics. Eager to learn about a different variety of topics related to academia, like scientific divulgation, which he currently works on in the ACS Student Chapter at National University of Colombia. He is also passionate about education and community service, he has participated in different environmental care activities and is part of the volunteer group of the Salesian Youth Movement led by the Salesians of Don Bosco.
Postgraduate Thesis
| Date | Title | Link |
|---|---|---|
| 2023 | Felipe de la Roche Zogby (E-mail: fde@unal.edu.co) “Algas pardas de la Isla de San Andrés, Caribe Colombiano: Caracterización molecular y metabolómica” (Brown Algae from San Andrés Island, Colombian Caribbean: Molecular and Metabolomic Characterization») Universidad Nacional De Colombia. Master in Chemistry, 2023. | Access the document |
| 2023 | Sara Paola Abril (E-mail: spabrilp@unal.edu.co) “Compuestos con posible actividad fotoprotectora a partir de extractos de macroalgas del caribe colombiano” (Compounds with Potential Photoprotective Activity from Extracts of Macroalgae in the Colombian Caribbean) Universidad Nacional De Colombia. Master in Chemistry, 2023. | Access the document |
| 2023 | Lady Yohanna Sepúlveda Sánchez. (E-mail: lysepulvedas@unal.edu.co) “Búsqueda de compuestos con posible actividad inhibitoria de enzimas de interés cosmético a partir de algas pardas del Caribe colombiano.» (Search for Compounds with Potential Inhibitory Activity on Enzymes of Cosmetic Interest from Brown Algae in the Colombian Caribbean) Universidad Nacional De Colombia. Master in Chemistry, 2023. | Access the document |
| 2022 | Yessica Lorena Miranda Martinez “Caracterización de los metabolitos secundarios producidos por la cepa IBUN 2755, involucrados en la actividad antimicrobiana y antifúngica, contra patógenos de arroz“ (Characterization of the Secondary Metabolites Produced by Strain IBUN 2755, Involved in Antimicrobial and Antifungal Activity Against Rice Pathogens). Universidad Nacional de Colombia. Master in Microbiology, 2022. | Access the document |
| 2022 | Jennifer Lorena Garcia Riaño “Estudio de los microesclerocios formados por el hongo entomopatógeno metarhizium sp. Mt004: producción, caracterización y actividad insecticida sobre chizas” (Study of the Microsclerotia Formed by the Entomopathogenic Fungus Metarhizium sp. Mt004: Production, Characterization, and Insecticidal Activity Against Chinch Bugs). Universidad Nacional De Colombia. Master in Chemistry, 2022. | Access the document |
| 2021 | Diana Marcela Vinchira Villarraga. “Bioprospección de bacterias aisladas de ambientes marinos con actividad biocontroladora frente a Fusarium oxysporum f. sp. lycopersici” (Bioprospecting of Bacteria Isolated from Marine Environments with Biocontrol Activity Against Fusarium oxysporum f. sp. lycopersici.).Universidad Nacional De Colombia. PhD in Biotechnology. 2021. | Access the document |
| 2020 | Abel Mateo Forero Tunjano “Evaluación in vitro e in silico de la actividad citotóxica de una librería de diterpenos de origen marino” (In Vitro and In Silico Evaluation of the Cytotoxic Activity of a Library of Marine-Derived Diterpenes) Universidad Nacional De Colombia. Master in Pharmacy, 2020 | Access the document |
| 2019 | Juan David Cárdenas Martínez “Evaluación de la producción metabólica de un aislamiento bacteriano obtenido de ambientes marinos para el control de fitopatógenos” (Evaluation of Metabolic Production of a Bacterial Isolate Obtained from Marine Environments for the Control of Phytopathogens) Universidad Nacional De Colombia. Master in Chemistry, 2019. | Access the document |
| 2018 | Judith Naranjo Gaybor “Estudio de bioprospección de compuestos inhibidores de la comunicación celular (QS) como estrategia de control de agentes fitopatógenos” (Bioprospecting Study of Compounds Inhibiting Cell-to-Cell Communication (Quorum Sensing) as a Strategy for Controlling Phytopathogenic Agents) Universidad Nacional De Colombia. PhD in Chemistry. I-2018. | Access the document |
| 2018 | Luz Adriana Bentancur Jaramillo “Actinobacterias Marinas como fuente de compuestos con actividad biológica para el control de fitopatógenos“ (Marine Actinobacteria as a Source of Compounds with Biological Activity for the Control of Phytopathogens) Universidad Nacional De Colombia. PhD in Chemistry. I-2018 | Access the document |
| 2018 | Juan David Cárdenas Martínez. “Evaluación de la producción metabólica de un aislamiento bacteriano obtenido de ambientes marinos para el control de agentes fitopatógenos” Universidad Nacional De Colombia. Master in Chemistry, 2018. | Access the document |
| 2018 | Jhoan Gabriel Monzón Daza. “Estudio metabólico de hojas de Passiflora ligularis juss y su relación con la actividad inhibitoria sobre α-amilasa y α-glucosidasa” (Metabolic Study of Leaves from Passiflora ligularis Juss and Its Relationship with Inhibitory Activity on α-Amylase and α-Glucosidase) Universidad Nacional De Colombia. Master in Chemistry, 2018. | Access the document |
| 2018 | Paola Andrea Martínez Buitrago “Co-cultivo de microorganismos de origen marino como estrategia para la producción diferencial de metabolitos especializados” (Co-Cultivation of Marine-Derived Microorganisms as a Strategy for the Differential Production of Specialized Metabolites) Universidad Nacional De Colombia. Master in Chemistry, 2018 | Access the document |
| 2018 | Carlos Andres Puentes “Bacterias marinas como fuente de compuestos con actividad insecticida contra Collaria scenica” (Marine Bacteria as a Source of Compounds with Insecticidal Activity Against Collaria scenica) Universidad Nacional De Colombia. Master in Chemistry, 2018 | Access the document |
| 2018 | Carlos Alberto Bernal Rodríguez “Desarrollo de un sistema de liberación modificada de un extracto estandarizado de Physalis peruviana L. aplicando el método de secado por aspersión” (Development of a Modified Release System for a Standardized Extract of Physalis peruviana L. Using the Spray Drying Method) Universidad Nacional De Colombia. PhD in Pharmacy, 2018 | Access the document |
| 2017 | Claudia Andrea Bautista Rodríguez «Una mirada al estado actual de la investigación en Productos Naturales Marinos de Colombia» (A Look at the Current State of Research on Marine Natural Products in Colombia) Universidad Nacional De Colombia. Master in Chemistry, 2017. | Access the document |
| 2017 | Paola Andrea Buitrago Rubiano “Estudio de diterpenos marinos de algas del género Dictyota del Caribe colombiano” (Study of Marine Diterpenes from Dictyota Algae in the Colombian Caribbean) Universidad Nacional De Colombia. Master in Chemistry, 2017 | Access the document |
| 2017 | Farja Isabel Ayala “Búsqueda de compuestos con posible actividad insecticida a partir de cianobacterias marinas del caribe colombiano” (Search for Compounds with Potential Insecticidal Activity from Marine Cyanobacteria in the Colombian Caribbean) Universidad Nacional De Colombia. Master in Chemistry, 2017 | Access the document |
| 2017 | Norman F. Urrego “Contribución al estudio fitoquímico y a la evaluación de la actividad antiinflamatoria de las hojas de badea (Passiflora quadrangularis) y gulupa (Passiflora edulis var edulis)” (Contribution to the Phytochemical Study and Evaluation of the Anti-Inflammatory Activity of the Leaves of Badea (Passiflora quadrangularis) and Gulupa (Passiflora edulis var. edulis)) Universidad Nacional De Colombia. Master in Pharmacy, 2017. | Access the document |
| 2017 | Laura Milena Becerra Real “Evaluación del perfil metabólico de un consorcio de cianobacterias bentónicas arrecifales del Caribe colombiano bajo condiciones cultivo” (Evaluation of the Metabolic Profile of a Consortium of Benthic Reef Cyanobacteria from the Colombian Caribbean Under Cultivation Conditions) Universidad Nacional de Colombia. Master in Microbiology, 2017 | Access the document |
| 2016 | Fabián Amaya “Obtención de diterpenos marinos con posible actividad antiviral incrementada” (Extraction of Marine Diterpenes with Potentially Enhanced Antiviral Activity) Universidad Nacional De Colombia. Master in Chemistry, 2016. | Access the document |
| 2016 | Adriana Rocío Romero Otero “Búsqueda de compuestos con actividad antimicrobiana a partir de hongos aislados de ambientes marinos. Fase I.” (Search for Compounds with Antimicrobial Activity from Fungi Isolated from Marine Environments. Phase I) Universidad Nacional De Colombia. Master in Chemistry, 2016. | Access the document |
| 2015 | Carolina Meneses Macías “Saponinas y flavonoides de Passiflora ligularis y evaluación de su actividad antiinflamatoria” (Saponins and Flavonoids from Passiflora ligularis and Evaluation of Their Anti-Inflammatory Activity) Universidad Nacional De Colombia. Master in Chemistry, 2015. | Access the document |
Publications
| Pardo-Solórzano, M.V.; Modesti Costa, G.; Castellanos, L. “Passiflora by-products and their potential use as cosmetic ingredients” Scientia Pharmaceutica. 2024, 92(4), 57 (1-25). https://doi.org/10.3390/scipharm92040057 |
| Garcia-Riaño, J. L.; Barrera, G. P.; Castellanos, L.; Villamizar, L. F. “Microsclerotia from Metarhizium robertsii: production, ultrastructural analysis, robustness, and insecticidal activity” Fungal Biology 2024, 128, 1643–1656. https://doi.org/10.1016/j.funbio.2024.01.006 |
| Castellanos, L. “RETOS EN EL ESTUDIO DE PRODUCTOS NATURALES MARINOS: el suminstro” in “Colombia Bioazul: Dos Mares Un País; Territorios por Explorar” Ed Nestor Hernando Campos Campos- Universidad Nacional de Colombia, Primera edición, Febrero del 2023, ISBN 978-958-505-136-2. ISBN digital 978-958-505-137-9 |
| Ramos Calderón, P.F.; Rodriguez Pérez, W.; Castrillon Rivera, B.; Ramos Rodriguez, F. A.; Suárez Salazar, J.C. “Potential use of Siparuna guianensis essential oil for the control of Moniliophthora roreri in cacao” Acta Agronómica 2023-02-21 DOI: 10.15446/acag.v71n2.90056 |
| Vanessa Urrea-Victoria, Vanessa Geraldes, Ernani Pinto, Leonardo Castellanos “Photosynthetic pigments and photoprotective metabolites of Colombian pacific marine macroalgae in response to contrasting ultraviolet-index periods” Journal of Experimental Marine Biology and Ecology 564 (2023) 151908. https://doi.org/10.1016/j.jembe.2023.151908 |
| Candra-Purnama, P.; Castellanos, L.; Verpoorte, R. “Do Fungicides Affect Alkaloid Production in Catharanthus roseus (L.) G. Don. Seedlings?” Molecules 2023, 28, 1405. https://doi.org/10.3390/molecules28031405 |
| Moreira Borges, R.; Neves Costa, F.; Oliveira Chagas, F.; Magno Teixeira, A.; Yoon, J.; Barczyszyn Weiss, M.; Manoel Crnkovic, C.; Cesar Pilon, A.; Carius Garrido, B.; Adriana Betancur, L.; Mateo Forero Tunjano, A.; Castellanos, L.; Ramos, F.; Tallarico Pupo, M.; Kuhn, S. “Data Fusion-based Discovery (DAFdiscovery) pipeline to aid compound annotation and bioactive compound discovery across diverse spectral data” Phytochemical Analysis, 2022, https://doi.org/10.1002/pca.3178 |
| Bautista, C. A.; Puentes, C.A.; Vargas-Peláez, C.M.; Santos-Acevedo, M.; Ramos, F.A.; Gómez-León, J.; Castellanos, L. “The state of the art of marine natural products in Colombia” Rev. Colomb. Quim., vol. 51, no. 1, pp. 24-39, 2022. DOI: https://doi.org/10.15446/rev.colomb.quim.v51n1.100644 |
| Urrego, N.; Sepúlveda, P.; Aragón, M.; Ramos, F.A.; Costa, G.; Ospina, L.F.; Castellanos, L. “Flavonoids and saponins from Passiflora edulis f. edulis leaves (purple passion fruit) and its potential anti-inflammatory activity” Journal of Pharmacy and Pharmacology, 2021, 1–9. https://doi.org/10.1093/jpp/rgab117 |
| Gómez, A.G; Ramos, FA; Sinuco, DC “Screening of volatile organic compounds from actinobacteria for the control of phytopathogen Colletotrichum gloeosporioides”. Biocontrol Science and Technology 2021, DOI: 10.1080/09583157.2021.1918635 |
| Forero, A. M.; Castellanos, L.; Sandoval-Hernández, A.G.; Magalhães, A.; Tinoco, L.W.; Lopez-Vallejo, F.; Ramos, F.A. “Integration of NMR studies, computational predictions, and in vitro assays in the search of marine diterpenes with antitumor activity” Chemical Biology & Drug Design. 2021; 98:507–521. https://doi.org/10.1111/cbdd.13907. |
| Rodríguez, W.; Duque, C.; Zea, S.E.; Castellanos, L.; Ramos, F.A.; Forero, A. M.; Osorno, O. «Study of phospholipid fatty acids of sponges” Ocean and Coastal Research. 2021, v69:e21016, https://doi.org/10.1590/2675-2824069.21-005wr . |
| Amaya-Garcia, F.; Cirne-Santos, C.; de Souza Barros, C.; Viana Pinto, A. ; Sanchez Nunes, L.; Laneuville Teixeira, V.; Resende, J.; Ramos, F.; N. P. Paixão, I.; Castellanos, L. «Semisynthesis of Dolabellane Diterpenes: Oxygenated Analogues with Increased Activity against Zika and Chikungunya Viruses» Journal of Natural Products 2021 84 (4), 1373-1384 DOI: https://doi.org/10.1021/acs.jnatprod.1c00199 |
| Monzón-Daza, G.; Meneses-Macías, C.; Forero, A.M.; Rodríguez, J.; Aragón, M.; Jiménez, C.; Ramos, F.A.; Castellanos, L. “Identification of α-amylase and α-glucosidase inhibitors and ligularoside A, a new triterpenoid saponin from Passiflora ligularis Juss (Sweet Granadilla) leaves by NMR based metabolomic study” Journal Agric. Food Chem. 2021, 69, 9, 2919–2931 https://dx.doi.org/10.1021/acs.jafc.0c07850 |
| Vinchira-Villarraga, D.; Castellanos, L.; Moreno-Sarmiento, N.; Suarez-Moreno, Z.; Ramos, F. A. “Antifungal activity of marine-derived Paenibacillus sp. PNM200 against Fusarium oxysporum f. sp. lycopersici, the causal agent of tomato vascular wilt” Biological Control. Volume 154, March 2021, 104501 https://doi.org/10.1016/j.biocontrol.2020.104501 |
| Monzón Daza, G: Aragón Novoa, D.M.; Ramos Rodríguez, F.A.; Castellanos, L.; López-Vallejo, F. “Estudio in silico y evaluación in vitro de la actividad inhibitoria de flavonoides y saponinas identificados en hojas de Passiflora ligularis Juss. sobre las enzimas α-amilasa y α-glucosidasa” in Passiflora ligularis Juss. (granadilla): Estudios químicos y farmacológicos de una planta con potencial terapéutico. Ed by Diana Marcela Arago, Universidad Nacional de Colombia, Primera edición, agosto 2021 ISBN papel 978-958-794-642-0 ISBN digital 978-958-794-643-7 |
| Meneses Macías, C.; Monzón Daza, G.; Modesti Costa, G.; Aragón Novoa, D.M.; Ramos Rodríguez, F.A.; Castellanos Hernández, L. “Evaluación de la actividad antiinflamatoria del extracto acuoso, la fracción butanólica y compuestos identificados en las hojas de Passiflora ligularis Juss” in Passiflora ligularis Juss. (granadilla): Estudios químicos y farmacológicos de una planta con potencial terapéutico. Ed by Diana Marcela Arago, Universidad Nacional de Colombia, Primera edición, agosto 2021 ISBN papel 978-958-794-642-0 ISBN digital 978-958-794-643-7 |
| Betancur, L.A.;Forero, M.; Vinchira-Villarraga, D.M.; Cárdenas,J.D.; Romero-Otero, A.; Chagas, F.; Pupo, M.; Castellanos, L.; Ramos, F. “NMR-based metabolic profiling to follow the production of anti-phytopathogenic compounds in the culture of the marine strain Streptomyces sp. PNM-9” Microbiological Research 2020, 239, 126507. https://doi.org/10.1016/j.micres.2020.126507 |
| Castellanos, L.; Naranjo-Gaybor, S.J.; Forero, M.; Morales, G.; Wilson, E.G.; Ramos, F.A.; Choi, Y.H. “Metabolic fingerprinting of banana passion fruits and its correlation with quorum quenching activity”, Phytochemistry, 2020, 172, 112272. https://doi.org/10.1016/j.phytochem.2020.112272 |
| Mejía, C; Espinel, C; Forero, M; Ramos, F; Brandão, P; Villamizar, L. “Improving ecological fitness of Beauveria bassiana conidia to control the sugar cane borer Diatraea saccharalis” Biocontrol Science and Technology, 2020, DOI: 10.1080/09583157.2020.1738343 |
| Coconubo-Guio, L.C.; Castellanos, L.; Sinuco-León, D. C. “Actividad fungicida de compuestos orgánicos volátiles de la bacteria Paenibacillus contra Colletotrichum gloeosporioides» Rev. Colomb. Quim. 2020, vol. 49(1), pp. 20-25. DOI: http://dx.doi.org/10.15446/rev.colomb.quim.v1n49.81996 |
| Molina, S.L.; Forero, AM; Ayala, FI; Puyana, M.; Zea, S.; Castellanos, L.; Muñoz, D.; Arboleda, G.; Sandoval-Hernández, A. G.; Ramos, F.A. “Metabolic Profiling of the Soft Coral Erythropodium caribaeorum (Alcyonacea: Anthothelidae) from the Colombian Caribbean Reveals Different Chemotypes”. Marine Drugs, 2020, 18 (1), 4. https://doi.org/10.3390/md18010004 |
| Díaz-Cárdenas, C.; Rojas, L.Y.; Fiorentino, S.; Cala, M.P.; Díaz, J.I.; Ramos, F.A.; Armengaud, J.; Restrepo, S.; Baena, S. Bioactive Potential of Extracts of Labrenzia aggregata Strain USBA 371, a Halophilic Bacterium Isolated from a Terrestrial Source. Molecules 2020, 25, 2546. 29 May 2020. https://doi.org/10.3390/molecules25112546 |
| Martínez, P.; Ramos, F.A.; Castellanos, L. «Binary co-culture selection from marine-derived microorganisms for differential production of specialized metabolites» Quim. Nova 2019, 42(7), 713-719. https://doi.org/10.21577/0100-4042.20170388 |
| Bernal, C.A.; Bassani, V.L.; Castellanos, L: Ramos Rodriguez, F.A. “Development of an oral control release system from Physalis peruviana L. fruits extract based on the co-spray-drying method Powder Technology” Powder Technology. 2019, 354: 676-688. https://doi.org/10.1016/j.powtec.2019.06.024 |
| Puyana, M.; Prato, J.A.; Nieto, C.F.; Ramos, F.A.; Castellanos, L.; Pinzón, P.; Zárate, J.C. “Experimental approaches for the evaluation of allelopathic interactions between hermatypic Corals and marine benthic cyanobacteria In the colombian caribbean” Acta Biol. Colomb. 2019, 24(2):243-254. https://doi.org/10.15446/abc.v24n2.72706 |
| Betancur, L.A.; Forero, A.M.; Romero-Otero, A. R.; Sepúlveda, L.Y.; Moreno-Sarmiento, N.C.; Castellanos, L.; Ramos, F.A. “Cyclic tetrapeptides from the marine strain Streptomyces sp. PNM-161a with activity against rice phytopathogenic bacteria” The Journal of Antibiotics volume 72, pages 744–751. https://doi.org/10.1038/s41429-019-0201-0 |
| Mejía-Agudelo, L.; Rojas, M.A.; Guerrero-Pabón, M.F.; Ramos, F.A.; Castellanos, L.; Marín-Loaiza, J. C: “Antidepressant-Like Effects of Methanol Extract and Fractions of Hypericum Juniperinum Kunth in the Forced Swimming Test» Pharmacognosy Magazine 2019; 15: 226-31. http://www.phcog.com/text.asp?2019/15/61/226/253474 |
| López, G., Yate, C., Ramos, F. et al. Production of Polyunsaturated Fatty Acids and Lipids from Autotrophic, Mixotrophic and Heterotrophic cultivation of Galdieria sp. strain USBA-GBX-832. Sci Rep 9, 10791 (2019). |
| Ayala, F.I.; Becerra, L.M.; Quintana, J.; Bayona, L:M:; Ramos, F.A:; Puyana, M.; Duque, F.; Castellanos, L. “Environmental and cultured cyanobacteria as source of Aedes aegypti larvicides” Universitas Scientiarum, 24 (3): 465-496, 2019. https://doi.org/10.11144/Javeriana.SC24-3.eacc |
| Rozo, G.; Rozo, C.; Puyana, M.; Ramos, FA; Almonacid, C.; Castro, H. “Two compounds of the Colombian algae Hypnea musciformis prevent oxidative damage in human low density lipoproteins LDLs” Journal of Functional Foods, 2019. DOI: 10.1016/j.jff.2019.06.001 |
| Suarez-Moreno, Z.; Vinchira, D.; Vergara, D.; Castellanos, L.; Ramos, F.; Guarnaccia, C.; Degrassi, G.; Venturi, V.; Moreno-Sarmiento, N. “Plant-growth promotion and biocontrol properties of three Streptomyces spp. isolates to control bacterial rice pathogens” Frontiers in Microbiology, section Microbial Physiology and Metabolism. 2019, 10:290 doi: https://doi.org/10.3389/fmicb.2019.00290 |
| Rubiano-Buitrago, P.; Duque, F.; Puyana, M.; Ramos, F.A.; Castellanos, L. “Bacterial biofilm inhibitor Diterpenes from Dictyota pinnatifida collected from the Colombian Caribbean Sea” Phytochemistry letters 2019 30, 75-80. https://doi.org/10.1016/j.phytol.2019.01.021 |
| Bauer, K.; Puyana, M.; Castellanos, L.; Tello, E. “New Diterpenes Isolated from the Colombian Caribbean Soft Coral Pseudoplexaura flagellosa and Their Cytotoxic Properties” Rec. Nat. Prod. 2019, 13:3, 243-253 http://doi.org/10.25135/rnp.100.18.07.325.1 |
| Bernal C-A, Ramos FA, Baena Y. 2019. Dry Powder Formulation from Physalis Peruviana L. Fruits Extract With Antidiabetic Activity Formulated Via Co-Spray Drying. International Journal of Applied Pharmaceutics, VOL 11, ISSUE 3 (MAY-JUN), 2019. DOI https://doi.org/10.22159/ijap.2019v11i3.29520 |
| Sepúlveda, P.M.; Costa, G.M., Aragón, D.M.; Ramos, F.A.; Castellanos, L. “Analysis of vitexin in aqueous extracts and commercial products of some Andean Passiflora species by UHPLC-DAD» Journal of Applied Pharmaceutical Science 2018, Vol. 8(09), 081-086. DOI: 10.7324/JAPS.2018.8912 |
| Castellanos, F.; Amaya-García, F.A.; Tello, E.; Ramos, F.A:; Umaña, A., Puyana, M.; Resende, J.L.C.; Castellanos, L. “Screening of acetylcholinesterase inhibitors in marine organisms from the Caribbean Sea” Natural Product Research, 2018 https://doi.org/10.1080/14786419.2018.1481837 |
| Leal, C.; Rojas, J.L.; Valencia-Islas, N.A.; Castellanos, L. “New β-orcinol depsides from Hypotrachyna caraccensis, a lichen from the páramo ecosystem and their free radical scavenging activity» Natural Product Research, 2018, 32(12), 1375-1382 DOI: 10.1080/14786419.2017.1346639 |
| Gazola, A. C.; Costa, G. M.; Zucolotto, S.M.; Castellanos, L.; Ramos, F.A.; Monteiro de Lima, T.C.; Schenkelahe, E. P. “Sedative activity of flavonoids from Passiflora quadrangularis is mediated through the GABAergic pathway” Biomedicine & Pharmacotherapy 2018, 100, 388-393. https://doi.org/10.1016/j.biopha.2018.02.002 |
| Bernal, C.A.; Castellanos, L.; Aragón, D.M.; Martínez-Matamoros, D.; Jiménez, C.; Baena,Y.; Ramos, F.A. “Peruvioses A to F, sucrose esters from the exudate of Physalis peruviana fruit as α-amylase inhibitors” Carbohydrate Research 2018,461, 4-10. https://doi.org/10.1016/j.carres.2018.03.003 |
| Ayres, A.S.F.S.J.; Santos, W.; Junqueira-Ayres, D.D.; Costa, G.M., Ramos, F.A.; Castellanos, L., Alves, J.S.F.; Asth, L.; de Medeiros, I.U.; Zucolotto, S.M.; Gavioli, E.C. “Monoaminergic neurotransmission is mediating the antidepressant-like effects of Passiflora edulis Sims fo. edulis” Neuroscience Letters 2017, 660, 79-85. https://doi.org/10.1016/j.neulet.2017.09.010 |
| Cardona, M.I.; Toro, R.M.; Costa, G.M.; Ospina, L.F.; Castellanos, L.; Ramos, F.A.; Aragón, D.M. “Influence of extraction process on antioxidant activity and rutin content in Physalis peruviana calyces extract” Journal of Applied Pharmaceutical Science 2017, 7 (06), pp. 164-168. DOI: 10.7324/JAPS.2017.70623 |
| Amaya-García, F.; Ramos, F.A.; Sánchez-Nuñez, L.; Puyana, M.; Nunes de Palmer Paixao, I.C.; Laneuville Teixeira, V.; Castellanos, L. “Dolabellane diterpenes from Eunicea octocorals and determination of their anti HSV-1 activity” Rev. Colomb. Quim. 2017, 46(1), 5-12. DOI: https://doi.org/10.15446/rev.colomb.quim.v1n1.62830 |
| Betancur, L.A.; Naranjo-Gaybor, S.J.; Vinchira-Villarraga, D.M.; Moreno-Sarmiento, N.C.; Maldonado, L.M.; Suarez-Moreno, Z.R.; Acosta-González, A.; Padilla-Gonzalez, G.F.; Puyana, M.; Castellanos, L.; Ramos, F.A. “Marine Actinobacteria as a source of compounds for phytopathogen control: An integrative metabolic-profiling / bioactivity and taxonomical approach” PLoS ONE 2017, 12(2): e0170148. doi:10.1371/journal.pone.0170148 |
| A. Pinzón; D. Martinez-Matamoros; L. Castellanos; C. Duque; C. Jiménez; J. Rodríguez; F. A. Ramos “Cereusitin A, a cyclic tetrapeptide from a Bacillus cereus strain isolated from the soft coral Antillogorgia (syn. Pseudopterogorgia) b” Tetrahedron letters 2017, 58, 634–637 https://doi.org/10.1016/j.tetlet.2017.01.002 |
| Díaz-Cárdenas C, Cantillo A, Rojas LY, Sandoval T, Fiorentino S, Robles J, Ramos FA, Zambrano MM, Baena S. 2017. Microbial diversity of saline environments: searching for cytotoxic activities. AMB Express, 7, 223 https://doi.org/10.1186/s13568-017-0527-6. |
| Ullrich, S.f.; Averesch, N.J.H.; Castellanos, L.; Choi, Y.H.; Rothauer, A.; Kayser, O. “Discrimination of wild types and hybrids of Duboisia myoporoides and Duboisia leichhardtii at different growth stages using 1H NMR-based metabolite profiling and tropane alkaloids-targeted HPLC-MS analysis” Phytochemistry 2016, 131, 44–56. https://doi.org/10.1016/j.phytochem.2016.08.008 |
| Costa, G.M.; Gazola, A.C.; Zucolotto, S.M.; Castellanos, L.; Ramos, FA; Reginatto, FH; Schenkel, EP. “Chemical profiles of traditional preparations of four South American Passiflora species by chromatographic and capillary electrophoretic techniques” Brazilian Journal of Pharmacognosy 2016, 26, 451-458. https://doi.org/10.1016/j.bjp.2016.02.005 |
| Martínez, D.; Laiton-Fonseca, M.; Rodríguez, F.A.; Duque, C.; Castellanos, L. “Screening of marine bacterial strains as source of quorum sensing inhibitors (QSI): first chemical study of Oceanobacillus profundus (RKHC-62b)” VITAE 2016 23, 30-47. DOI http://dx.doi.org/10.17533/udea.vitae.v23n1a04 |
| Martínez, Y.; Vanegas, G.; Reina, L.; Mayorga, H.; Arévalo-Ferro, C.; Rodríguez, F.A.; Duque, C.; Castellanos, L. “Biofilm inhibition activity of compounds isolated from two Eunicea species collected at the Caribbean Sea” Brazilian Journal of Pharmacogosy 2015, 25 (6), 605–611 https://doi.org/10.1016/j.bjp.2015.08.007 |
| Ayres, A.; Araújo, L.; Soares, T.; Costa, G.; Reginatto, F.; Ramos, F.A.; Castellanos, L.; Shenkel, E.; Soares-Rachetti, V.; Zucolotto, S.; Gaviolia, E “Comparative central effects of the aqueous leaf extract of two populations of Passiflora edulis” Brazilian Journal of Pharmacogosy 2015, 25, 499–505. https://doi.org/10.1016/j.bjp.2015.06.007 |
| G. Costa; P. A Cárdenas; A. C Gazola; D. M. Aragón-Novoa; L. Castellanos; F. H. Reginatto; F. A. Ramos; E. Schenkel “Isolation of C-glycosylflavonoids with <alpha>-glucosidase inhibitory activity from Passiflora bogotensis Benth by gradient High-Speed Counter-Current Chromatography” Journal of Chromatography B. 2015, 990, 104-110. https://doi.org/10.1016/j.jchromb.2015.03.015 |
| G. Costa; S. M Zucolotto; L. Castellanos; F. A. Ramos; T. C Monteiro de Lima; E. P Schenkel “Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from Passiflora quadrangularis Linneaus pericarp.” Brazilian Journal of Pharmacognosy 2015, 25(2) 158-163. https://doi.org/10.1016/j.bjp.2015.03.009 |
| J. Quintana; J. Brango-Vanegas; G. Costa; L. Castellanos; C. Arévalo-Ferro; C. Duque “Marine organisms as source of extracts to disrupt bacterial communication: Bioguided isolation and identification of quorum sensing inhibitors from Ircinia felix” Brazilian Journal of Pharmacognosy 2015, 25 (3), 1997-207 https://doi.org/10.1016/j.bjp.2015.03.013 |
Research Projects
Research on natural products as a source of compounds with value as cosmetic
“Bioprospección y Química de Algas del Caribe” MinCiencias. Fecha Inicio: 20/11/2020 a 20/11/2025.
“Estudio de la diversidad química de Passifloras en Colombia y Brasil: aproximación metabolómica y potencial biológico de subproductos agroindustriales”. MinCiencias. Dirección de la Pontificia Universidad Javeriana. Fecha Inicio: 27/07/2021 Fecha Finalización: 27/07/2023
Marine microorganisms and biocontrol of pest in agriculture
Promoción de la sostenibilidad en cultivos de importancia económica para el país basada en manejo biológico: arroz y aguacate Hass”. MinCiencias. Fecha Inicio: 28/05/2021 a Fecha Finalización: 28/05/2024
“Bacterias marinas para el control de fitopatógenos fase ii: estudio químico y variación de la producción metabólica” Código: 42187. CONVOCATORIA PARA EL FORTALECIMIENTO DE ALIANZAS INTERDISCIPLINARIAS DE INVESTIGACIÓN Y CREACIÓN ARTÍSTICA DE LA SEDE BOGOTÁ DE LA UNIVERSIDAD NACIONAL DE COLOMBIA, 2018.
Escalamiento industrial y validación comercial de ACTYBAC(R), un agente de control biológico para los cultivos de arroz (Oriza sativa) y tomate (Solanum lycopersicum) en Colombia. Código: 35499. Colciencias 2017-2019
Evaluación de la actividad biológica de compuestos volátiles liberados por bacterias aisladas de ambientes marinos. Universidad Nacional de Colombia. 2017-2018.37546.
“Evaluación y caracterización de una colección de aislamientos bacterianos provenientes del Caribe Colombiano para el control de fitopatógenos”. Universidad Nacional de Colombia. 2017-2018. Código: 37151.
“Evaluación y caracterización de una colección de aislamientos bacterianos provenientes del caribe Colombiano para el control de fitopatógenos”. Código: 35280. Colciencias.
Innovación, ciencia y tecnología para productores de leche en la provincia de Ubaté Cundinamarca. Código: 22750. Fondo de CT+I REGALÍAS.
Marine microorganisms and biocontrol of pest in agriculture
“Búsqueda del potencial citotóxico de productos naturales marinos en algas y octocorales” Código: 45403 Convocatoria: CONVOCATORIA PARA EL FOMENTO DE ALIANZAS DE INVESTIGACIÓN ENTRE LAS FACULTADES DE CIENCIAS DE LAS SEDES BOGOTÁ, MANIZALES Y MEDELLÍN DE LA UNIVERSIDAD NACIONAL DE COLOMBIA 2019.
“Búsqueda de nuevas alternativas terapéuticas para erradicar la infección por Helicobacter pylori: Una estrategia para reducir el riesgo de cáncer gástrico” Colciencias 2019 Código 42364
Estudio de la actividad antidiabética de un extracto nanovehiculizado de hojas de Passiflora ligularis (granadilla). Código: 38223. Colciencias 2018-2021
Bioprospección de Productos naturales marinos Fase II: Algas y Cianobacterias bentónicas arrecifales.Código: 37507 Universidad Nacional de Colombia. 2017-2018.
Contribución al estudio fitoquímico y a la evaluación de la actividad antiinflamatoria de algunas especies del género Passiflora. Código: 23562. Universidad Nacional de Colombia. 2015-2016.
“Terpenos marinos y derivados semisintéticos con posible actividad antiviral incrementada”. Universidad Nacional de Colombia. Código: 28200.
Actinobacterias marinas como fuente de compuestos con actividad biológica. Fase I Universidad Nacional de Colombia. Código: 23604.
Information of interest
| Video |
|---|
| Conference full professor Leonardo Castellanos. “Un Balance del Estudio de las Moléculas del Mar”. – Link |
| Conference full professor “Biotecnología azul: ¿cómo pescar las moléculas del mar?” Banco de la República – Link |
| Conference TEDxUExternado. “El tesoro azul de Colombia”. Carmenza Duque. – Link |
Regulations
Contact Information
For more information about this Research Group, do not hesitate to contact us.
lcastellanosh@unal.edu.co
faramosr@unal.edu.co
Phone Number
(+57 601) 316 5000 Ext. 14451
Buisness Hours
Monday – Friday
08:30 – 16:00
Dirección
Laboratorio de Producto Naturales Marinos 401-1 Edif. 452 de Posgrados de Química, Universidad Nacional de Colombia, Sede Bogotá.